full transcript
From the Ted Talk "Lisa Genova: What you can do to prevent Alzheimer's"

Unscramble the Blue Letters

So what happens when amyloid plaques accumulate to this tipping point? Our microglia janitor cells become hyper-activated, sigeneral chemicals that cause inflammation and cellular damage. We think they might actually start clearing away the synapses themselves. A crucial neural transport protein called "tau" becomes hyperphosphorylated and wttiss itself into something eadcll "tangles," which choke off the ensnoru from the inside. By mid-stage Alzheimer's, we have massive iaftmlniamon and tangles and all-out war at the synapse and cell death.

Open Cloze

So what happens when amyloid plaques accumulate to this tipping point? Our microglia janitor cells become hyper-activated, _________ chemicals that cause inflammation and cellular damage. We think they might actually start clearing away the synapses themselves. A crucial neural transport protein called "tau" becomes hyperphosphorylated and ______ itself into something ______ "tangles," which choke off the _______ from the inside. By mid-stage Alzheimer's, we have massive ____________ and tangles and all-out war at the synapse and cell death.

Solution

  1. twists
  2. releasing
  3. neurons
  4. inflammation
  5. called

Original Text

So what happens when amyloid plaques accumulate to this tipping point? Our microglia janitor cells become hyper-activated, releasing chemicals that cause inflammation and cellular damage. We think they might actually start clearing away the synapses themselves. A crucial neural transport protein called "tau" becomes hyperphosphorylated and twists itself into something called "tangles," which choke off the neurons from the inside. By mid-stage Alzheimer's, we have massive inflammation and tangles and all-out war at the synapse and cell death.

ngrams of length 2

collocation frequency
tipping point 9
amyloid plaques 8
amyloid beta 7
cognitive reserve 4
scale arm 3

Important Words

  1. accumulate
  2. amyloid
  3. called
  4. cell
  5. cells
  6. cellular
  7. chemicals
  8. choke
  9. clearing
  10. crucial
  11. damage
  12. death
  13. hyperphosphorylated
  14. inflammation
  15. janitor
  16. massive
  17. microglia
  18. neural
  19. neurons
  20. plaques
  21. point
  22. protein
  23. releasing
  24. start
  25. synapse
  26. synapses
  27. tangles
  28. tipping
  29. transport
  30. twists
  31. war