full transcript

From the Ted Talk by Christopher Bahl: A new type of medicine, custom-made with tiny proteins

Unscramble the Blue Letters

To test our method out, we generated a sirees of constrained peptides that have a wide variety of different shapes. Many of these had never been seen in nature before. Then we went into the laboratory and produced these peptides. Next, we determined their molecular srueutrtcs, using experiments. When we compared our deinegsd moelds with the real molecular structures, we found that our software can position individual atoms with an accuracy that's at the limit of what's possible to measure. Three years ago, this couldn't be done. But today, we have the ability to create dieesgnr peptides with shapes that are custom-tailored for drug dleeeopnmvt.

Open Cloze

To test our method out, we generated a ______ of constrained peptides that have a wide variety of different shapes. Many of these had never been seen in nature before. Then we went into the laboratory and produced these peptides. Next, we determined their molecular __________, using experiments. When we compared our ________ ______ with the real molecular structures, we found that our software can position individual atoms with an accuracy that's at the limit of what's possible to measure. Three years ago, this couldn't be done. But today, we have the ability to create ________ peptides with shapes that are custom-tailored for drug ___________.

Solution

  1. designed
  2. series
  3. models
  4. structures
  5. development
  6. designer

Original Text

To test our method out, we generated a series of constrained peptides that have a wide variety of different shapes. Many of these had never been seen in nature before. Then we went into the laboratory and produced these peptides. Next, we determined their molecular structures, using experiments. When we compared our designed models with the real molecular structures, we found that our software can position individual atoms with an accuracy that's at the limit of what's possible to measure. Three years ago, this couldn't be done. But today, we have the ability to create designer peptides with shapes that are custom-tailored for drug development.

Frequently Occurring Word Combinations

ngrams of length 2

collocation frequency
constrained peptides 8
constrained peptide 5
drug development 4
peptide drugs 3
extra chemical 2
chemical bonds 2
biologic drugs 2
development pipeline 2

ngrams of length 3

collocation frequency
constrained peptide drugs 2
extra chemical bonds 2
drug development pipeline 2

Important Words

  1. ability
  2. accuracy
  3. atoms
  4. compared
  5. constrained
  6. create
  7. designed
  8. designer
  9. determined
  10. development
  11. drug
  12. experiments
  13. generated
  14. individual
  15. laboratory
  16. limit
  17. measure
  18. method
  19. models
  20. molecular
  21. nature
  22. peptides
  23. position
  24. produced
  25. real
  26. series
  27. shapes
  28. software
  29. structures
  30. test
  31. today
  32. variety
  33. wide
  34. years