full transcript

From the Ted Talk by Lara Durgavich: An evolutionary perspective on human health and disease

Unscramble the Blue Letters

seiutds from the 1980s support this idea. The segment of the American Jewish population that had the highest frequency of Tay-Sachs crrriaes teacrd their descent to those European countries where the incidence of TB was highest. The benefits of being a Tay-Sachs carrier were higesht in those places where the risk of death due to TB was greatest. And while it was unclear in the 1970s or '80s how exactly the Tay-Sachs mutation offered proeittcon against TB, recent work has identified how the mutation increases cellular defenses against the bacterium. So heterozygote advantage can help explain why problematic vrnseois of genes persist at high frequencies in certain ptiopnouals.

Open Cloze

_______ from the 1980s support this idea. The segment of the American Jewish population that had the highest frequency of Tay-Sachs ________ ______ their descent to those European countries where the incidence of TB was highest. The benefits of being a Tay-Sachs carrier were _______ in those places where the risk of death due to TB was greatest. And while it was unclear in the 1970s or '80s how exactly the Tay-Sachs mutation offered __________ against TB, recent work has identified how the mutation increases cellular defenses against the bacterium. So heterozygote advantage can help explain why problematic ________ of genes persist at high frequencies in certain ___________.

Solution

  1. populations
  2. protection
  3. traced
  4. versions
  5. studies
  6. highest
  7. carriers

Original Text

Studies from the 1980s support this idea. The segment of the American Jewish population that had the highest frequency of Tay-Sachs carriers traced their descent to those European countries where the incidence of TB was highest. The benefits of being a Tay-Sachs carrier were highest in those places where the risk of death due to TB was greatest. And while it was unclear in the 1970s or '80s how exactly the Tay-Sachs mutation offered protection against TB, recent work has identified how the mutation increases cellular defenses against the bacterium. So heterozygote advantage can help explain why problematic versions of genes persist at high frequencies in certain populations.

Frequently Occurring Word Combinations

ngrams of length 2

collocation frequency
natural selection 6
evolutionary medicine 5
sickle cell 5
heterozygote advantage 4
cell anemia 4
red blood 4
eastern european 3
normal copy 2
unusually high 2
high rate 2
ashkenazi population 2
defective gene 2
problems today 2
ashkenazi jews 2
blood cells 2
human health 2
proximate explanations 2
ultimate perspective 2

ngrams of length 3

collocation frequency
sickle cell anemia 4
unusually high rate 2
red blood cells 2

Important Words

  1. advantage
  2. american
  3. bacterium
  4. benefits
  5. carrier
  6. carriers
  7. cellular
  8. countries
  9. death
  10. defenses
  11. descent
  12. due
  13. european
  14. explain
  15. frequencies
  16. frequency
  17. genes
  18. greatest
  19. heterozygote
  20. high
  21. highest
  22. idea
  23. identified
  24. incidence
  25. increases
  26. jewish
  27. mutation
  28. offered
  29. persist
  30. places
  31. population
  32. populations
  33. problematic
  34. protection
  35. risk
  36. segment
  37. studies
  38. support
  39. tb
  40. traced
  41. unclear
  42. versions
  43. work