full transcript

From the Ted Talk by Jennifer Doudna: How CRISPR lets us edit our DNA

Unscramble the Blue Letters

The reason we envisioned using the CRISPR system for gomnee einenernigg is because cells have the atlbiiy to detect broken DNA and repair it. So when a plant or an animal cell detects a double-stranded break in its DNA, it can fix that break, either by painstg together the ends of the broken DNA with a little, tiny change in the sequence of that position, or it can repair the break by integrating a new piece of DNA at the site of the cut. So if we have a way to introduce double-stranded breaks into DNA at precise places, we can tgerigr cells to repair those breaks, by either the disruption or incorporation of new genetic iooinamfrtn. So if we were able to program the CRISPR technology to make a break in DNA at the position at or near a mutation causing cystic fsirbois, for example, we could trigger cells to reapir that mutation.

Open Cloze

The reason we envisioned using the CRISPR system for ______ ___________ is because cells have the _______ to detect broken DNA and repair it. So when a plant or an animal cell detects a double-stranded break in its DNA, it can fix that break, either by _______ together the ends of the broken DNA with a little, tiny change in the sequence of that position, or it can repair the break by integrating a new piece of DNA at the site of the cut. So if we have a way to introduce double-stranded breaks into DNA at precise places, we can _______ cells to repair those breaks, by either the disruption or incorporation of new genetic ___________. So if we were able to program the CRISPR technology to make a break in DNA at the position at or near a mutation causing cystic ________, for example, we could trigger cells to ______ that mutation.

Solution

  1. trigger
  2. repair
  3. engineering
  4. ability
  5. pasting
  6. genome
  7. information
  8. fibrosis

Original Text

The reason we envisioned using the CRISPR system for genome engineering is because cells have the ability to detect broken DNA and repair it. So when a plant or an animal cell detects a double-stranded break in its DNA, it can fix that break, either by pasting together the ends of the broken DNA with a little, tiny change in the sequence of that position, or it can repair the break by integrating a new piece of DNA at the site of the cut. So if we have a way to introduce double-stranded breaks into DNA at precise places, we can trigger cells to repair those breaks, by either the disruption or incorporation of new genetic information. So if we were able to program the CRISPR technology to make a break in DNA at the position at or near a mutation causing cystic fibrosis, for example, we could trigger cells to repair that mutation.

Frequently Occurring Word Combinations

ngrams of length 2

collocation frequency
crispr technology 13
viral dna 5
crispr system 3
genome engineering 3
tiny change 3
protein called 2
ethical issues 2
crispr locus 2
broken dna 2
trigger cells 2
genetic information 2
clinical application 2
careful consideration 2

Important Words

  1. ability
  2. animal
  3. break
  4. breaks
  5. broken
  6. causing
  7. cell
  8. cells
  9. change
  10. crispr
  11. cut
  12. cystic
  13. detect
  14. detects
  15. disruption
  16. dna
  17. ends
  18. engineering
  19. envisioned
  20. fibrosis
  21. fix
  22. genetic
  23. genome
  24. incorporation
  25. information
  26. integrating
  27. introduce
  28. mutation
  29. pasting
  30. piece
  31. places
  32. plant
  33. position
  34. precise
  35. program
  36. reason
  37. repair
  38. sequence
  39. site
  40. system
  41. technology
  42. tiny
  43. trigger