full transcript

From the Ted Talk by Jay Bradner: Open-source cancer research

Unscramble the Blue Letters

And so we started to work on this problem. We developed libraries of compounds and eventually arrived at this and similar substances called JQ1. Now, not being a drug company, we could do certain things, we had certain flexibilities, that I rpeesct that a pharmaceutical industry doesn't have. We just started mailing it to our friends. I have a small lab. We tgouhht we'd just send it to pleope and see how the molecule behaves. We sent it to Oxford, England, where a gruop of talented crreyrlsghalpotas provided this picture, which helped us understand exactly how this molecule is so potent for this protein target. It's what we call a perfect fit of shape citpemteolnramy, or hand in govle.

Open Cloze

And so we started to work on this problem. We developed libraries of compounds and eventually arrived at this and similar substances called JQ1. Now, not being a drug company, we could do certain things, we had certain flexibilities, that I _______ that a pharmaceutical industry doesn't have. We just started mailing it to our friends. I have a small lab. We _______ we'd just send it to ______ and see how the molecule behaves. We sent it to Oxford, England, where a _____ of talented _________________ provided this picture, which helped us understand exactly how this molecule is so potent for this protein target. It's what we call a perfect fit of shape _______________, or hand in _____.

Solution

  1. thought
  2. complementarity
  3. glove
  4. respect
  5. people
  6. group
  7. crystallographers

Original Text

And so we started to work on this problem. We developed libraries of compounds and eventually arrived at this and similar substances called JQ1. Now, not being a drug company, we could do certain things, we had certain flexibilities, that I respect that a pharmaceutical industry doesn't have. We just started mailing it to our friends. I have a small lab. We thought we'd just send it to people and see how the molecule behaves. We sent it to Oxford, England, where a group of talented crystallographers provided this picture, which helped us understand exactly how this molecule is so potent for this protein target. It's what we call a perfect fit of shape complementarity, or hand in glove.

Frequently Occurring Word Combinations

ngrams of length 2

collocation frequency
rare cancer 3
prototype drug 3
drug substance 2
discovery chemistry 2
protein target 2
chest tube 2
clinical trial 2
chemical identity 2

Important Words

  1. arrived
  2. behaves
  3. call
  4. called
  5. company
  6. complementarity
  7. compounds
  8. crystallographers
  9. developed
  10. drug
  11. england
  12. eventually
  13. fit
  14. flexibilities
  15. friends
  16. glove
  17. group
  18. hand
  19. helped
  20. industry
  21. lab
  22. libraries
  23. mailing
  24. molecule
  25. oxford
  26. people
  27. perfect
  28. pharmaceutical
  29. picture
  30. potent
  31. problem
  32. protein
  33. respect
  34. send
  35. shape
  36. similar
  37. small
  38. started
  39. substances
  40. talented
  41. target
  42. thought
  43. understand
  44. work