full transcript

From the Ted Talk by Craig Venter: Watch me unveil "synthetic life"

Unscramble the Blue Letters

So the team developed new debugging srtofawe, where we could test each synthetic fragment to see if it would grow in a background of wild type DNA. And we found that 10 out of the 11 100,000-base pair pieces we synthesized were completely acructae and compatible with a life-forming suecqene. We narrowed it down to one fragment; we sequenced it and found just one base pair had been deleted in an eitsseanl gene. So accuracy is essential. There's parts of the genome where it cannot tolerate even a single error, and then there's parts of the genome where we can put in large blocks of DNA, as we did with the wrtramkeas, and it can tolerate all kinds of errors. So it took about three months to find that error and repair it. And then elray one mionnrg, at 6 a.m. we got a text from Dan saying that, now, the first blue ciooelns existed.

Open Cloze

So the team developed new debugging ________, where we could test each synthetic fragment to see if it would grow in a background of wild type DNA. And we found that 10 out of the 11 100,000-base pair pieces we synthesized were completely ________ and compatible with a life-forming ________. We narrowed it down to one fragment; we sequenced it and found just one base pair had been deleted in an _________ gene. So accuracy is essential. There's parts of the genome where it cannot tolerate even a single error, and then there's parts of the genome where we can put in large blocks of DNA, as we did with the __________, and it can tolerate all kinds of errors. So it took about three months to find that error and repair it. And then _____ one _______, at 6 a.m. we got a text from Dan saying that, now, the first blue ________ existed.

Solution

  1. software
  2. essential
  3. morning
  4. sequence
  5. early
  6. watermarks
  7. colonies
  8. accurate

Original Text

So the team developed new debugging software, where we could test each synthetic fragment to see if it would grow in a background of wild type DNA. And we found that 10 out of the 11 100,000-base pair pieces we synthesized were completely accurate and compatible with a life-forming sequence. We narrowed it down to one fragment; we sequenced it and found just one base pair had been deleted in an essential gene. So accuracy is essential. There's parts of the genome where it cannot tolerate even a single error, and then there's parts of the genome where we can put in large blocks of DNA, as we did with the watermarks, and it can tolerate all kinds of errors. So it took about three months to find that error and repair it. And then early one morning, at 6 a.m. we got a text from Dan saying that, now, the first blue colonies existed.

Frequently Occurring Word Combinations

ngrams of length 2

collocation frequency
genetic code 4
smallest genome 4
mycoplasma genitalium 3
bacterial chromosome 3
synthetic dna 3
team developed 3
bacterial cell 2
recipient cell 2
slow growth 2
bacterial chromosomes 2
base pairs 2
writing messages 2
technical side 2

Important Words

  1. accuracy
  2. accurate
  3. background
  4. base
  5. blocks
  6. blue
  7. colonies
  8. compatible
  9. completely
  10. dan
  11. debugging
  12. deleted
  13. developed
  14. dna
  15. early
  16. error
  17. errors
  18. essential
  19. existed
  20. find
  21. fragment
  22. gene
  23. genome
  24. grow
  25. kinds
  26. large
  27. months
  28. morning
  29. narrowed
  30. pair
  31. parts
  32. pieces
  33. put
  34. repair
  35. sequence
  36. sequenced
  37. single
  38. software
  39. synthesized
  40. synthetic
  41. team
  42. test
  43. text
  44. tolerate
  45. type
  46. watermarks
  47. wild